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Sigma® Life Science Enhances OligoArchitect Online qPCR Tool

St. Louis, Mo. - October 13, 2011 - Sigma-Aldrich® (Nasdaq: SIAL), today announced that Sigma Life Science, the innovative biological products and services research business, released a new version of OligoArchitect™, the comprehensive, easy-to-use online tool for automated design of primers and probes for quantitative real-time PCR assays. Powered by the industry standard Beacon Designer™ platform from PREMIER Biosoft, OligoArchitect is a free, robust design tool that complements Sigma Life Science's portfolio of qPCR probes, reagents, and oligonucleotide services. To access OligoArchitect, visit sigma.com/probedesignonline.

OligoArchitect simplifies compliance with Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines with new features, such as primer and probe homology searching, template secondary structure analysis, and by providing the ability to design across exon splice sites. Additional features include automatic retrieval of template sequences, visualization of the template with positional display of regions of interest, design quality ratings, and tools for alternative and multiplex designs.

"OligoArchitect was designed to empower both qPCR novices and experts to quickly design sophisticated and MIQE-compliant primers and probes without having to shuffle data between multiple tools," said Tom Russell, Product Manager, Sigma Life Science. "Novices especially will appreciate OligoArchitect's straightforward, learn-as-one-works design. If additional information is required, a guide to all parameters as well as consultative technical support are available."

OligoArchitect Online currently supports detection chemistries for both SYBR® Green I primers and dual-labeled probes, making it ideally suited to key applications in traditional PCR, endpoint genotyping, gene expression analysis, genomic copy number determination, allele discrimination, SNP detection, haplotyping, and multiplexing.

For more information about Sigma Life Science's custom qPCR probes, please visit sigma.com/probes.

Cautionary Statement: The foregoing release contains forward-looking statements that can be identified by terminology such as "ideally suited" or similar expressions, or by expressed or implied discussions regarding potential future revenues from products derived therefrom. You should not place undue reliance on these statements. Such forward-looking statements reflect the current views of management regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause actual results to be materially different from any future results, performance or achievements expressed or implied by such statements. There can be no guarantee that OligoArchitect software will asisst the Company to achieve any particular levels of revenue in the future. In particular, management's expectations regarding products associated with OligoArchitect software could be affected by, among other things, unexpected regulatory actions or delays or government regulation generally; the Company's ability to obtain or maintain patent or other proprietary intellectual property protection; competition in general; government, industry and general public pricing pressures; the impact that the foregoing factors could have on the values attributed to the Company's assets and liabilities as recorded in its consolidated balance sheet, and other risks and factors referred to in Sigma-Aldrich's current Form 10-K on file with the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those anticipated, believed, estimated or expected. Sigma-Aldrich is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

About Sigma Life Science: Sigma Life Science is a Sigma-Aldrich business that represents the Company's leadership in innovative biological products and services for the global life science market and offers an array of biologically-rich products and reagents that researchers use in scientific investigation. Product areas include biomolecules, genomics and functional genomics, cells and cell-based assays, transgenics, protein assays, stem cell research, epigenetics and custom services/oligonucleotides. Sigma Life Science also provides an extensive range critical bioessentials like biochemicals, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, amino acids and their derivatives, and cell culture media.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development, and as key components in pharmaceutical, diagnostic and other high technology manufacturing. We have customers in life science companies, university and government institutions, hospitals and in industry. Over one million scientists and technologists use our products. Sigma-Aldrich operates in 40 countries and has 8,300 employees providing excellent service worldwide. We are committed to accelerating our Customers' success through leadership in Life Science, High Technology and Service. For more information about Sigma-Aldrich, please visit our award winning web site at www.sigma-aldrich.com.

Sigma-Aldrich and Sigma are trademarks of Sigma-Aldrich Co, LLC registered in the US and other countries.  OligoArchitect is a trademark of Sigma-Aldrich Co, LLC. SYBR is a registered trademark of Molecular Probes, Inc. Beacon Designer is a trademark of PREMIER Biosoft Intl.

FORWARD INQUIRIES TO: Sigma-Aldrich
Sarah Bruno
+ (1) 314-286-7810
sarah.bruno@sial.com

MEDIA INQUIRIES: Harris D. McKinney, Inc
Alan Zachary, Ph.D.
+ (1) 312-506-5220
azachary@harrisdmckinney.com

Ryan Ferrell
+ (1) 312-506-5202
rferrell@harrisdmckinney.com



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